6X4G
Crystal structure of ICOS in complex with ICOS-L and an anti ICOS-L VNAR domain
Summary for 6X4G
Entry DOI | 10.2210/pdb6x4g/pdb |
Descriptor | Inducible T-cell costimulator, ICOS ligand, anti ICOS-L VHH domain VNAR, ... (6 entities in total) |
Functional Keywords | immune checkpoint, receptors, glycoproteins, immune system, t-cell, b-cell |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 57412.44 |
Authors | Rujas, E.,Sicard, T.,Julien, J.P. (deposition date: 2020-05-22, release date: 2020-10-14, Last modification date: 2023-10-18) |
Primary citation | Rujas, E.,Cui, H.,Sicard, T.,Semesi, A.,Julien, J.P. Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Nat Commun, 11:5066-5066, 2020 Cited by PubMed: 33033255DOI: 10.1038/s41467-020-18828-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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