6X4G
Crystal structure of ICOS in complex with ICOS-L and an anti ICOS-L VNAR domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Inducible T-cell costimulator | polymer | 119 | 13412.2 | 1 | UniProt (Q9Y6W8) Pfam (PF15910) | Homo sapiens (Human) | Activation-inducible lymphocyte immunomediatory molecule |
| 2 | B (C) | ICOS ligand | polymer | 240 | 26771.8 | 1 | UniProt (O75144) Pfam (PF07686) Pfam (PF22705) | Homo sapiens (Human) | B7 homolog 2,B7-H2,B7-like protein Gl50,B7-related protein 1,B7RP-1 |
| 3 | C (N) | anti ICOS-L VHH domain VNAR | polymer | 130 | 13987.4 | 1 | Orectolobus maculatus | ||
| 4 | D, E (B, D) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 5 | F, H, I, J, K... (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 6 | G (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) |
Sequence modifications
A: 19 - 129 (UniProt: Q9Y6W8)
C: 19 - 248 (UniProt: O75144)
| PDB | External Database | Details |
|---|---|---|
| Gly 130 | - | expression tag |
| Thr 131 | - | expression tag |
| Glu 132 | - | expression tag |
| Asn 133 | - | expression tag |
| Leu 134 | - | expression tag |
| Tyr 135 | - | expression tag |
| Phe 136 | - | expression tag |
| Gln 137 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Thr 17 | - | cloning artifact |
| Gly 18 | - | cloning artifact |
| Gly 249 | - | expression tag |
| Thr 250 | - | expression tag |
| Glu 251 | - | expression tag |
| Asn 252 | - | expression tag |
| Leu 253 | - | expression tag |
| Tyr 254 | - | expression tag |
| Phe 255 | - | expression tag |
| Gln 256 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 54171.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1821.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1419.3 | |
| All* | Total formula weight | 57412.4 |
