6WE2
Human PARP14 (ARTD8), catalytic fragment in complex with RBN012759
Summary for 6WE2
Entry DOI | 10.2210/pdb6we2/pdb |
Descriptor | Isoform 1 of Protein mono-ADP-ribosyltransferase PARP14, 7-(cyclopropylmethoxy)-5-fluoro-2-{[(trans-4-hydroxycyclohexyl)sulfanyl]methyl}quinazolin-4(3H)-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | parp14, artd8, monoparp, adp ribosylation, inhibitor complex, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 44127.06 |
Authors | Swinger, K.K.,Schenkel, L.B.,Kuntz, K.W. (deposition date: 2020-04-01, release date: 2021-03-24, Last modification date: 2023-10-18) |
Primary citation | Schenkel, L.B.,Molina, J.R.,Swinger, K.K.,Abo, R.,Blackwell, D.J.,Lu, A.Z.,Cheung, A.E.,Church, W.D.,Kunii, K.,Kuplast-Barr, K.G.,Majer, C.R.,Minissale, E.,Mo, J.R.,Niepel, M.,Reik, C.,Ren, Y.,Vasbinder, M.M.,Wigle, T.J.,Richon, V.M.,Keilhack, H.,Kuntz, K.W. A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants. Cell Chem Biol, 28:1158-, 2021 Cited by PubMed: 33705687DOI: 10.1016/j.chembiol.2021.02.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.66 Å) |
Structure validation
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