6W4K
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with CC-90011
Summary for 6W4K
Entry DOI | 10.2210/pdb6w4k/pdb |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, 4-[2-(4-aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl]-2-fluorobenzonitrile, ... (5 entities in total) |
Functional Keywords | human lsd1 inhibitor-complex, flavoprotein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 89774.17 |
Authors | Hosfield, D.J. (deposition date: 2020-03-11, release date: 2020-10-21, Last modification date: 2023-10-18) |
Primary citation | Kanouni, T.,Severin, C.,Cho, R.W.,Yuen, N.Y.,Xu, J.,Shi, L.,Lai, C.,Del Rosario, J.R.,Stansfield, R.K.,Lawton, L.N.,Hosfield, D.,O'Connell, S.,Kreilein, M.M.,Tavares-Greco, P.,Nie, Z.,Kaldor, S.W.,Veal, J.M.,Stafford, J.A.,Chen, Y.K. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J.Med.Chem., 63:14522-14529, 2020 Cited by PubMed: 33034194DOI: 10.1021/acs.jmedchem.0c00978 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.93 Å) |
Structure validation
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