6VL4
Crystal Structure of mPGES-1 bound to DG-031
Summary for 6VL4
Entry DOI | 10.2210/pdb6vl4/pdb |
Descriptor | Prostaglandin E synthase, (2R)-cyclopentyl{4-[(quinolin-2-yl)methoxy]phenyl}acetic acid, octyl beta-D-glucopyranoside, ... (5 entities in total) |
Functional Keywords | mpges-1, membrane protein, isomerase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 18365.81 |
Authors | Ho, J.D.,Lee, M.R.,Rauch, C.T.,Aznavour, K.,Park, J.S.,Luz, J.G.,Antonysamy, S.,Condon, B.,Maletic, M.,Zhang, A.,Hickey, M.J.,Hughes, N.E.,Chandrasekhar, S.,Sloan, A.V.,Gooding, K.,Harvey, A.,Yu, X.P.,Kahl, S.D.,Norman, B.H. (deposition date: 2020-01-22, release date: 2020-12-02, Last modification date: 2020-12-16) |
Primary citation | Ho, J.D.,Lee, M.R.,Rauch, C.T.,Aznavour, K.,Park, J.S.,Luz, J.G.,Antonysamy, S.,Condon, B.,Maletic, M.,Zhang, A.,Hickey, M.J.,Hughes, N.E.,Chandrasekhar, S.,Sloan, A.V.,Gooding, K.,Harvey, A.,Yu, X.P.,Kahl, S.D.,Norman, B.H. Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP). Biochim Biophys Acta Gen Subj, 1865:129800-129800, 2020 Cited by PubMed: 33246032DOI: 10.1016/j.bbagen.2020.129800 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
Download full validation report