6V5P
EGFR(T790M/V948R) in complex with LN2725
Summary for 6V5P
Entry DOI | 10.2210/pdb6v5p/pdb |
Descriptor | Epidermal growth factor receptor, 4-[4-(4-fluorophenyl)-2-(3-methoxypropyl)-1H-imidazol-5-yl]-2-phenyl-3H-pyrrolo[2,3-b]pyridine, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | egfr, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 151729.77 |
Authors | Heppner, D.E.,Eck, M.J. (deposition date: 2019-12-04, release date: 2020-04-22, Last modification date: 2023-10-11) |
Primary citation | Heppner, D.E.,Gunther, M.,Wittlinger, F.,Laufer, S.A.,Eck, M.J. Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. J.Med.Chem., 63:4293-4305, 2020 Cited by PubMed: 32243152DOI: 10.1021/acs.jmedchem.0c00200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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