6TCZ
Leishmania tarentolae proteasome 20S subunit complexed with LXE408
Summary for 6TCZ
Entry DOI | 10.2210/pdb6tcz/pdb |
EMDB information | 10462 |
Descriptor | Proteasome subunit alpha type, Proteasome subunit beta, Proteasome subunit family protein, ... (15 entities in total) |
Functional Keywords | proteasome complex, inhibitor, peptidase, hydrolase |
Biological source | Leishmania donovani More |
Total number of polymer chains | 28 |
Total formula weight | 848731.37 |
Authors | Srinivas, H. (deposition date: 2019-11-07, release date: 2020-08-26, Last modification date: 2024-05-22) |
Primary citation | Nagle, A.,Biggart, A.,Be, C.,Srinivas, H.,Hein, A.,Caridha, D.,Sciotti, R.J.,Pybus, B.,Kreishman-Deitrick, M.,Bursulaya, B.,Lai, Y.H.,Gao, M.Y.,Liang, F.,Mathison, C.J.N.,Liu, X.,Yeh, V.,Smith, J.,Lerario, I.,Xie, Y.,Chianelli, D.,Gibney, M.,Berman, A.,Chen, Y.L.,Jiricek, J.,Davis, L.C.,Liu, X.,Ballard, J.,Khare, S.,Eggimann, F.K.,Luneau, A.,Groessl, T.,Shapiro, M.,Richmond, W.,Johnson, K.,Rudewicz, P.J.,Rao, S.P.S.,Thompson, C.,Tuntland, T.,Spraggon, G.,Glynne, R.J.,Supek, F.,Wiesmann, C.,Molteni, V. Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. J.Med.Chem., 63:10773-10781, 2020 Cited by PubMed: 32667203DOI: 10.1021/acs.jmedchem.0c00499 PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)