6TBX
Trypanosoma brucei PTR1 (TbPTR1) in complex with a tricyclic-based inhibitor
Summary for 6TBX
Entry DOI | 10.2210/pdb6tbx/pdb |
Descriptor | Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-bis(azanyl)-9~{H}-pyrimido[4,5-b]indol-6-ol, ... (7 entities in total) |
Functional Keywords | trypanosoma brucei, pteridine reductase, tbptr1, tricyclic based inhibitor, oxidoreductase |
Biological source | Trypanosoma brucei brucei More |
Total number of polymer chains | 4 |
Total formula weight | 126739.81 |
Authors | Landi, G.,Tassone, G.,Pozzi, C.,Mangani, S. (deposition date: 2019-11-04, release date: 2020-06-03, Last modification date: 2024-01-24) |
Primary citation | Landi, G.,Linciano, P.,Tassone, G.,Costi, M.P.,Mangani, S.,Pozzi, C. High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor. Acta Crystallogr D Struct Biol, 76:558-564, 2020 Cited by PubMed: 32496217DOI: 10.1107/S2059798320004891 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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