6T8Q
HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide
Summary for 6T8Q
Entry DOI | 10.2210/pdb6t8q/pdb |
Descriptor | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (2~{R})-1-[6-methyl-5-(oxan-4-yl)-7-oxidanylidene-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]-~{N}-(phenylmethyl)pyrrolidine-2-carboxamide, CADMIUM ION, ... (6 entities in total) |
Functional Keywords | alpha & beta protein, plp-dependent transferase, kat ii, kynurenine am, proteros biostructures gmbh, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 52438.49 |
Authors | Blaesse, M.,Venalainen, J. (deposition date: 2019-10-24, release date: 2020-03-04, Last modification date: 2024-01-24) |
Primary citation | Kalliokoski, T.,Rummakko, P.,Rantanen, M.,Blaesse, M.,Augustin, M.,Ummenthala, G.R.,Choudhary, S.,Venalainen, J. Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors. Bioorg.Med.Chem.Lett., 30:127060-127060, 2020 Cited by PubMed: 32113843DOI: 10.1016/j.bmcl.2020.127060 PDB entries with the same primary citation |
Experimental method |
Structure validation
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