6T8Q
HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006103 | biological_process | 2-oxoglutarate metabolic process |
A | 0006536 | biological_process | glutamate metabolic process |
A | 0008483 | molecular_function | transaminase activity |
A | 0009058 | biological_process | biosynthetic process |
A | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0033512 | biological_process | L-lysine catabolic process to acetyl-CoA via saccharopine |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0047315 | molecular_function | kynurenine-glyoxylate transaminase activity |
A | 0047536 | molecular_function | 2-aminoadipate transaminase activity |
A | 0047958 | molecular_function | glycine:2-oxoglutarate aminotransferase activity |
A | 0050094 | molecular_function | methionine-glyoxylate transaminase activity |
A | 0070189 | biological_process | kynurenine metabolic process |
A | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | binding site for residue MVQ A 501 |
Chain | Residue |
A | PRO18 |
A | SER143 |
A | ASN202 |
A | LLP263 |
A | LEU382 |
A | ARG399 |
A | HOH623 |
A | ILE19 |
A | MET22 |
A | GLY38 |
A | GLY39 |
A | TYR74 |
A | SER75 |
A | PRO76 |
A | TYR142 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue CD A 502 |
Chain | Residue |
A | CYS122 |
A | GLU126 |
A | HIS287 |
A | HOH601 |
A | HOH601 |
A | HOH702 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue CD A 503 |
Chain | Residue |
A | ASP169 |
A | ASP169 |
A | ARG172 |
A | GLU215 |
A | GLU215 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue CD A 504 |
Chain | Residue |
A | GLU0 |
A | MET1 |
A | ASP224 |
A | HOH679 |
site_id | AC5 |
Number of Residues | 2 |
Details | binding site for residue CD A 505 |
Chain | Residue |
A | ASP320 |
A | ASP324 |
site_id | AC6 |
Number of Residues | 1 |
Details | binding site for residue CD A 506 |
Chain | Residue |
A | HIS348 |
site_id | AC7 |
Number of Residues | 2 |
Details | binding site for residue CD A 507 |
Chain | Residue |
A | LEU149 |
A | CYS154 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue CD A 508 |
Chain | Residue |
A | ASP110 |
A | HOH724 |
site_id | AC9 |
Number of Residues | 1 |
Details | binding site for residue CD A 509 |
Chain | Residue |
A | GLU282 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue CL A 510 |
Chain | Residue |
A | GLN119 |
A | GLN119 |
A | LYS123 |
A | LYS123 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue ACT A 511 |
Chain | Residue |
A | SER35 |
A | GLY38 |
A | LEU40 |
A | SER401 |
A | SER403 |
A | SER404 |
A | HOH650 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 5 |
Details | BINDING: |
Chain | Residue | Details |
A | ARG20 | |
A | TYR74 | |
A | TYR142 | |
A | ASN202 | |
A | ARG399 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9WVM8 |
Chain | Residue | Details |
A | LYS69 | |
A | LYS179 | |
A | LYS422 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9WVM8 |
Chain | Residue | Details |
A | LLP263 | |
A | LYS339 | |
A | LYS367 |