6T8Q
HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| A | 0006536 | biological_process | glutamate metabolic process |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0033512 | biological_process | L-lysine catabolic process to acetyl-CoA via saccharopine |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0047315 | molecular_function | kynurenine-glyoxylate transaminase activity |
| A | 0047536 | molecular_function | 2-aminoadipate transaminase activity |
| A | 0047958 | molecular_function | glycine:2-oxoglutarate aminotransferase activity |
| A | 0050094 | molecular_function | methionine-glyoxylate transaminase activity |
| A | 0070189 | biological_process | kynurenine metabolic process |
| A | 0097052 | biological_process | L-kynurenine metabolic process |
| A | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue MVQ A 501 |
| Chain | Residue |
| A | PRO18 |
| A | SER143 |
| A | ASN202 |
| A | LLP263 |
| A | LEU382 |
| A | ARG399 |
| A | HOH623 |
| A | ILE19 |
| A | MET22 |
| A | GLY38 |
| A | GLY39 |
| A | TYR74 |
| A | SER75 |
| A | PRO76 |
| A | TYR142 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CD A 502 |
| Chain | Residue |
| A | CYS122 |
| A | GLU126 |
| A | HIS287 |
| A | HOH601 |
| A | HOH601 |
| A | HOH702 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CD A 503 |
| Chain | Residue |
| A | ASP169 |
| A | ASP169 |
| A | ARG172 |
| A | GLU215 |
| A | GLU215 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CD A 504 |
| Chain | Residue |
| A | GLU0 |
| A | MET1 |
| A | ASP224 |
| A | HOH679 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CD A 505 |
| Chain | Residue |
| A | ASP320 |
| A | ASP324 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue CD A 506 |
| Chain | Residue |
| A | HIS348 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue CD A 507 |
| Chain | Residue |
| A | LEU149 |
| A | CYS154 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue CD A 508 |
| Chain | Residue |
| A | ASP110 |
| A | HOH724 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue CD A 509 |
| Chain | Residue |
| A | GLU282 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 510 |
| Chain | Residue |
| A | GLN119 |
| A | GLN119 |
| A | LYS123 |
| A | LYS123 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 511 |
| Chain | Residue |
| A | SER35 |
| A | GLY38 |
| A | LEU40 |
| A | SER401 |
| A | SER403 |
| A | SER404 |
| A | HOH650 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG20 | |
| A | TYR74 | |
| A | TYR142 | |
| A | ASN202 | |
| A | ARG399 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9WVM8 |
| Chain | Residue | Details |
| A | LYS69 | |
| A | LYS179 | |
| A | LYS422 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9WVM8 |
| Chain | Residue | Details |
| A | LLP263 | |
| A | LYS339 | |
| A | LYS367 |
