6T8Q

HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006103	biological_process	2-oxoglutarate metabolic process
A	0006536	biological_process	glutamate metabolic process
A	0008483	molecular_function	transaminase activity
A	0009058	biological_process	biosynthetic process
A	0016212	molecular_function	kynurenine-oxoglutarate transaminase activity
A	0019477	biological_process	L-lysine catabolic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0042803	molecular_function	protein homodimerization activity
A	0047315	molecular_function	kynurenine-glyoxylate transaminase activity
A	0047536	molecular_function	2-aminoadipate transaminase activity
A	0047958	molecular_function	glycine:2-oxoglutarate aminotransferase activity
A	0050094	molecular_function	methionine-glyoxylate transaminase activity
A	0070189	biological_process	kynurenine metabolic process
A	1901605	biological_process	alpha-amino acid metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue MVQ A 501

Chain	Residue
A	PRO18
A	SER143
A	ASN202
A	LLP263
A	LEU382
A	ARG399
A	HOH623
A	ILE19
A	MET22
A	GLY38
A	GLY39
A	TYR74
A	SER75
A	PRO76
A	TYR142

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CD A 502

Chain	Residue
A	CYS122
A	GLU126
A	HIS287
A	HOH601
A	HOH601
A	HOH702

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CD A 503

Chain	Residue
A	ASP169
A	ASP169
A	ARG172
A	GLU215
A	GLU215

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CD A 504

Chain	Residue
A	GLU0
A	MET1
A	ASP224
A	HOH679

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CD A 505

Chain	Residue
A	ASP320
A	ASP324

---

site_id	AC6
Number of Residues	1
Details	binding site for residue CD A 506

Chain	Residue
A	HIS348

---

site_id	AC7
Number of Residues	2
Details	binding site for residue CD A 507

Chain	Residue
A	LEU149
A	CYS154

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CD A 508

Chain	Residue
A	ASP110
A	HOH724

---

site_id	AC9
Number of Residues	1
Details	binding site for residue CD A 509

Chain	Residue
A	GLU282

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CL A 510

Chain	Residue
A	GLN119
A	GLN119
A	LYS123
A	LYS123

---

site_id	AD2
Number of Residues	7
Details	binding site for residue ACT A 511

Chain	Residue
A	SER35
A	GLY38
A	LEU40
A	SER401
A	SER403
A	SER404
A	HOH650

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Transit peptide: {"description":"Mitochondrion","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	27
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9WVM8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9WVM8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---