6T8Q
HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | polymer | 452 | 50991.1 | 1 | UniProt (Q8N5Z0) Pfam (PF00155) In PDB | Homo sapiens (Human) | KAT/AadAT,2-aminoadipate aminotransferase,2-aminoadipate transaminase,Alpha-aminoadipate aminotransferase,AadAT,Kynurenine aminotransferase II,Kynurenine--oxoglutarate aminotransferase II,Kynurenine--oxoglutarate transaminase 2,Kynurenine--oxoglutarate transaminase II |
| 2 | A | (2~{R})-1-[6-methyl-5-(oxan-4-yl)-7-oxidanylidene-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]-~{N}-(phenylmethyl)pyrrolidine-2-carboxamide | non-polymer | 453.6 | 1 | Chemie (MVQ) | |||
| 3 | A | CADMIUM ION | non-polymer | 112.4 | 8 | Chemie (CD) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | water | water | 18.0 | 157 | Chemie (HOH) |
Sequence modifications
A: 1 - 425 (UniProt: Q8N5Z0)
| PDB | External Database | Details |
|---|---|---|
| Met -26 | - | initiating methionine |
| Ser -25 | - | expression tag |
| Tyr -24 | - | expression tag |
| Tyr -23 | - | expression tag |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Tyr -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Ile -13 | - | expression tag |
| Pro -12 | - | expression tag |
| Thr -11 | - | expression tag |
| Thr -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Asn -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Phe -5 | - | expression tag |
| Gln -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Met -1 | - | expression tag |
| Glu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 50991.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1447.3 | |
| All* | Total formula weight | 52438.5 |
