6T6A
Crystal structure of DYRK1A complexed with KuFal319 (compound 11)
Summary for 6T6A
Entry DOI | 10.2210/pdb6t6a/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, TETRAETHYLENE GLYCOL, SULFATE ION, ... (5 entities in total) |
Functional Keywords | dyrk1a, splicing kinase, kinase inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 171235.08 |
Authors | Chaikuad, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Kunick, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-10-18, release date: 2019-12-04, Last modification date: 2024-01-24) |
Primary citation | Lechner, C.,Flasshoff, M.,Falke, H.,Preu, L.,Loaec, N.,Meijer, L.,Knapp, S.,Chaikuad, A.,Kunick, C. [ b ]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors. Molecules, 24:-, 2019 Cited by PubMed: 31766108DOI: 10.3390/molecules24224090 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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