6T41
CDK8/Cyclin C in complex with N-(4-chlorobenzyl)isoquinolin-4-amine
Summary for 6T41
Entry DOI | 10.2210/pdb6t41/pdb |
Descriptor | Cyclin-dependent kinase 8, Cyclin-C, ~{N}-[(4-chlorophenyl)methyl]quinazolin-4-amine, ... (6 entities in total) |
Functional Keywords | cyclin-dependent kinase, inhibitor complex, mediator kinase module, mediator, transcriptional kinase, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 81361.98 |
Authors | Schneider, E.V.,Maskos, K.,Huber, R.,Kuhn, C.-D. (deposition date: 2019-10-11, release date: 2020-01-01, Last modification date: 2024-01-24) |
Primary citation | Klatt, F.,Leitner, A.,Kim, I.V.,Ho-Xuan, H.,Schneider, E.V.,Langhammer, F.,Weinmann, R.,Muller, M.R.,Huber, R.,Meister, G.,Kuhn, C.D. A precisely positioned MED12 activation helix stimulates CDK8 kinase activity. Proc.Natl.Acad.Sci.USA, 117:2894-2905, 2020 Cited by PubMed: 31988137DOI: 10.1073/pnas.1917635117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
Download full validation report