6T12

Crystal structure of YTHDC1 with fragment 30 (DHU_DC1_220)

Summary for 6T12

• Entry DOI: 10.2210/pdb6t12/pdb
• Descriptor: YTHDC1, ~{N},2,3-trimethyl-1~{H}-indole-5-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: fragment, complex, ythdc1, epitranscriptomic, rna binding protein
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 42915.20

Authors

Bedi, R.K.,Huang, D.,Sledz, P.,Caflisch, A. (deposition date: 2019-10-03, release date: 2020-03-04, Last modification date: 2024-01-24)

• Primary citation: Bedi, R.K.,Huang, D.,Wiedmer, L.,Li, Y.,Dolbois, A.,Wojdyla, J.A.,Sharpe, M.E.,Caflisch, A.,Sledz, P.; Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments.; Acs Chem.Biol., 15:618-625, 2020; PubMed: 32101404; DOI: 10.1021/acschembio.9b00894

Experimental method

X-RAY DIFFRACTION (1.46 Å)