6ST3

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 4-hydroxy-N-(4-phenoxybenzyl)-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide

Summary for 6ST3

• Entry DOI: 10.2210/pdb6st3/pdb
• Descriptor: Egl nine homolog 1, 4-oxidanyl-~{N}-[(4-phenoxyphenyl)methyl]-2-pyrazol-1-yl-pyrimidine-5-carboxamide, FORMIC ACID, ... (5 entities in total)
• Functional Keywords: oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 53049.87

Authors

Chowdhury, R.,Holt-Martyn, J.P.,Schofield, C.J. (deposition date: 2019-09-10, release date: 2019-12-04, Last modification date: 2024-01-24)

• Primary citation: Holt-Martyn, J.P.,Chowdhury, R.,Tumber, A.,Yeh, T.L.,Abboud, M.I.,Lippl, K.,Lohans, C.T.,Langley, G.W.,Figg Jr., W.,McDonough, M.A.,Pugh, C.W.,Ratcliffe, P.J.,Schofield, C.J.; Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.; Chemmedchem, 15:270-273, 2020; PubMed: 31751494; DOI: 10.1002/cmdc.201900557

Experimental method

X-RAY DIFFRACTION (2.426 Å)