6ST3
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 4-hydroxy-N-(4-phenoxybenzyl)-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Egl nine homolog 1 | polymer | 233 | 26036.6 | 2 | UniProt (Q9GZT9) Pfam (PF13640) In PDB | Homo sapiens (Human) | Hypoxia-inducible factor prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20 |
| 2 | A, B | 4-oxidanyl-~{N}-[(4-phenoxyphenyl)methyl]-2-pyrazol-1-yl-pyrimidine-5-carboxamide | non-polymer | 387.4 | 2 | Chemie (LUW) | |||
| 3 | A, B | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 4 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 5 | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A, B: 181 - 407 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| Gly 175 | - | expression tag |
| Ser 176 | - | expression tag |
| His 177 | - | expression tag |
| Met 178 | - | expression tag |
| Ala 179 | - | expression tag |
| Ser 180 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52073.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 976.7 | |
| All* | Total formula weight | 53049.9 |
