6ST3
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 4-hydroxy-N-(4-phenoxybenzyl)-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0031418 | molecular_function | L-ascorbic acid binding |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0031418 | molecular_function | L-ascorbic acid binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue LUW A 601 |
| Chain | Residue |
| A | ARG252 |
| A | TRP389 |
| A | PHE391 |
| A | FMT602 |
| A | MN603 |
| A | HOH717 |
| B | LEU404 |
| A | THR296 |
| A | TYR303 |
| A | TYR310 |
| A | HIS313 |
| A | ASP315 |
| A | ARG322 |
| A | HIS374 |
| A | VAL376 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 602 |
| Chain | Residue |
| A | TYR303 |
| A | TYR329 |
| A | ARG383 |
| A | ALA385 |
| A | LUW601 |
| A | HOH720 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 603 |
| Chain | Residue |
| A | HIS313 |
| A | ASP315 |
| A | HIS374 |
| A | LUW601 |
| A | HOH717 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 501 |
| Chain | Residue |
| B | HIS313 |
| B | ASP315 |
| B | HIS374 |
| B | LUW502 |
| B | HOH614 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for residue LUW B 502 |
| Chain | Residue |
| B | ARG252 |
| B | THR296 |
| B | MET299 |
| B | TYR303 |
| B | TYR310 |
| B | HIS313 |
| B | ASP315 |
| B | ASP320 |
| B | ARG322 |
| B | HIS374 |
| B | VAL376 |
| B | TRP389 |
| B | PHE391 |
| B | MN501 |
| B | FMT503 |
| B | HOH614 |
| B | HOH639 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 503 |
| Chain | Residue |
| B | TYR329 |
| B | VAL376 |
| B | ARG383 |
| B | LUW502 |
| B | HOH621 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 202 |
| Details | Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16782814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28594552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2G19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V18","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"21601578","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
