6R9H
Crystal structure of the PDZ tandem of syntenin in complex with fragment C58
Summary for 6R9H
Entry DOI | 10.2210/pdb6r9h/pdb |
Descriptor | Syntenin-1, PHOSPHATE ION, (2~{S})-2-[2-(4-chlorophenyl)sulfanylethanoylamino]-3-methyl-butanoic acid, ... (5 entities in total) |
Functional Keywords | signaling protein cell adhesion pdz domain syntenin syndecan drug design, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 73235.35 |
Authors | Feracci, M.,Barral, K. (deposition date: 2019-04-03, release date: 2021-02-03, Last modification date: 2024-01-24) |
Primary citation | Leblanc, R.,Kashyap, R.,Barral, K.,Egea-Jimenez, A.L.,Kovalskyy, D.,Feracci, M.,Garcia, M.,Derviaux, C.,Betzi, S.,Ghossoub, R.,Platonov, M.,Roche, P.,Morelli, X.,Hoffer, L.,Zimmermann, P. Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loadifing with syndecan and EpCAM cargo. J Extracell Vesicles, 10:e12039-e12039, 2020 Cited by PubMed: 33343836DOI: 10.1002/jev2.12039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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