6R8G

Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine

Summary for 6R8G

• Entry DOI: 10.2210/pdb6r8g/pdb
• Related: 5nfr
• Descriptor: Malate dehydrogenase, 4-[3,4-bis(fluoranyl)phenyl]-1,3-thiazol-2-amine, SODIUM ION, ... (5 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 4
• Total formula weight: 142986.98

Authors

Romero, A.R.,Calderone, V.,Gentili, M.,Lunev, S.,Groves, M.,Popowicz, G.,Domling, A.,Sattler, M. (deposition date: 2019-04-01, release date: 2020-04-15, Last modification date: 2024-01-24)

• Primary citation: Romero, A.R.,Lunev, S.,Popowicz, G.,Calderone, V.,Gentili, M.,Sattler, M.,Plewka, J.,Taube, M.,Kozak, M.,Holak, T.A.,Domling, A.,Groves, M.; A Fragment-Based Approach Identifies an Allosteric Pocket that Impacts Malate Dehydrogenase Activity; Commun Biol, 2021; DOI: 10.1038/s42003-021-02442-1

Experimental method

X-RAY DIFFRACTION (2 Å)