6QLX
Cathepsin-K in complex with fluoro-oxa-azabicyclo[3.3.0]octanyl containing inhibitor
Summary for 6QLX
Entry DOI | 10.2210/pdb6qlx/pdb |
Related | 6QL8 |
Descriptor | Cathepsin K, ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{S},6~{a}~{S})-6-fluoranyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-thiophen-2-yl-benzamide (3 entities in total) |
Functional Keywords | inhibitor complex, lysosomal cysteine proteinase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 24127.21 |
Authors | |
Primary citation | Derbyshire, D.J. Successful development of 3-oxohexahydrofuropyrrole amino acid amides as inhibitors of Cathepsin-K. To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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