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6PXW

Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex.

Summary for 6PXW
Entry DOI10.2210/pdb6pxw/pdb
EMDB information20522 20523
DescriptorInsulin receptor, Insulin (2 entities in total)
Functional Keywordsinsulin receptor, insulin, signaling protein-hormone complex, signaling protein/hormone
Biological sourceHomo sapiens (Human)
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Total number of polymer chains6
Total formula weight341348.74
Authors
Uchikawa, E.,Choi, E.,Shang, G.J.,Yu, H.T.,Bai, X.C. (deposition date: 2019-07-28, release date: 2019-09-04)
Primary citationUchikawa, E.,Choi, E.,Shang, G.,Yu, H.,Bai, X.C.
Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex.
Elife, 8:-, 2019
Cited by
PubMed: 31436533
DOI: 10.7554/eLife.48630
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.1 Å)
Structure validation

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