6PXW
Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Insulin receptor | polymer | 1354 | 153913.3 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) Pfam (PF07714) | Homo sapiens (Human) | IR |
| 2 | C, D, E, F (C, D, E, F) | Insulin | polymer | 74 | 8380.5 | 4 | UniProt (A6XGL2) Pfam (PF00049) | Homo sapiens (Human) |
Sequence modifications
A, B: 1 - 1343 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| Phe 960 | Tyr 987 | conflict |
| Thr 962 | Ser 989 | conflict |
| Asn 1120 | Asp 1147 | conflict |
| Ala 1333 | Arg 1360 | conflict |
| Ala 1334 | Ile 1361 | conflict |
| Ala 1335 | Leu 1362 | conflict |
| Ala 1337 | Leu 1364 | conflict |
| Leu 1344 | - | expression tag |
| Glu 1345 | - | expression tag |
| Ser 1346 | - | expression tag |
| Ser 1347 | - | expression tag |
| Gly 1348 | - | expression tag |
| Leu 1349 | - | expression tag |
| Glu 1350 | - | expression tag |
| Val 1351 | - | expression tag |
| Leu 1352 | - | expression tag |
| Phe 1353 | - | expression tag |
| Gln 1354 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 341348.7 | |
| All* | Total formula weight | 341348.7 |
