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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6PXW

Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001540molecular_functionamyloid-beta binding
A0002092biological_processpositive regulation of receptor internalization
A0003007biological_processheart morphogenesis
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
A0005009molecular_functioninsulin receptor activity
A0005159molecular_functioninsulin-like growth factor receptor binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005525molecular_functionGTP binding
A0005635cellular_componentnuclear envelope
A0005764cellular_componentlysosome
A0005768cellular_componentendosome
A0005770cellular_componentlate endosome
A0005886cellular_componentplasma membrane
A0005899cellular_componentinsulin receptor complex
A0005901cellular_componentcaveola
A0005979biological_processregulation of glycogen biosynthetic process
A0006355biological_processregulation of DNA-templated transcription
A0006468biological_processprotein phosphorylation
A0006898biological_processreceptor-mediated endocytosis
A0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
A0007186biological_processG protein-coupled receptor signaling pathway
A0007612biological_processlearning
A0007613biological_processmemory
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0008544biological_processepidermis development
A0008584biological_processmale gonad development
A0009887biological_processanimal organ morphogenesis
A0009897cellular_componentexternal side of plasma membrane
A0010008cellular_componentendosome membrane
A0010468biological_processregulation of gene expression
A0010557biological_processpositive regulation of macromolecule biosynthetic process
A0010906biological_processregulation of glucose metabolic process
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0019904molecular_functionprotein domain specific binding
A0030238biological_processmale sex determination
A0030295molecular_functionprotein kinase activator activity
A0030325biological_processadrenal gland development
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0031017biological_processexocrine pancreas development
A0031623biological_processreceptor internalization
A0031981cellular_componentnuclear lumen
A0031994molecular_functioninsulin-like growth factor I binding
A0031995molecular_functioninsulin-like growth factor II binding
A0032590cellular_componentdendrite membrane
A0032809cellular_componentneuronal cell body membrane
A0032869biological_processcellular response to insulin stimulus
A0038024molecular_functioncargo receptor activity
A0042593biological_processglucose homeostasis
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043235cellular_componentreceptor complex
A0043243biological_processpositive regulation of protein-containing complex disassembly
A0043410biological_processpositive regulation of MAPK cascade
A0043548molecular_functionphosphatidylinositol 3-kinase binding
A0043559molecular_functioninsulin binding
A0043560molecular_functioninsulin receptor substrate binding
A0044877molecular_functionprotein-containing complex binding
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045725biological_processpositive regulation of glycogen biosynthetic process
A0045821biological_processpositive regulation of glycolytic process
A0045840biological_processpositive regulation of mitotic nuclear division
A0045893biological_processpositive regulation of DNA-templated transcription
A0045995biological_processregulation of embryonic development
A0046326biological_processpositive regulation of D-glucose import
A0046718biological_processsymbiont entry into host cell
A0046777biological_processprotein autophosphorylation
A0048513biological_processanimal organ development
A0048639biological_processpositive regulation of developmental growth
A0048731biological_processsystem development
A0051130biological_processpositive regulation of cellular component organization
A0051239biological_processregulation of multicellular organismal process
A0051425molecular_functionPTB domain binding
A0051446biological_processpositive regulation of meiotic cell cycle
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060267biological_processpositive regulation of respiratory burst
A0070062cellular_componentextracellular exosome
A0071363biological_processcellular response to growth factor stimulus
A0097062biological_processdendritic spine maintenance
A0097242biological_processamyloid-beta clearance
A0150104biological_processtransport across blood-brain barrier
A1990535biological_processneuron projection maintenance
A2000194biological_processregulation of female gonad development
B0000166molecular_functionnucleotide binding
B0001540molecular_functionamyloid-beta binding
B0002092biological_processpositive regulation of receptor internalization
B0003007biological_processheart morphogenesis
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
B0005009molecular_functioninsulin receptor activity
B0005159molecular_functioninsulin-like growth factor receptor binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005525molecular_functionGTP binding
B0005635cellular_componentnuclear envelope
B0005764cellular_componentlysosome
B0005768cellular_componentendosome
B0005770cellular_componentlate endosome
B0005886cellular_componentplasma membrane
B0005899cellular_componentinsulin receptor complex
B0005901cellular_componentcaveola
B0005979biological_processregulation of glycogen biosynthetic process
B0006355biological_processregulation of DNA-templated transcription
B0006468biological_processprotein phosphorylation
B0006898biological_processreceptor-mediated endocytosis
B0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
B0007186biological_processG protein-coupled receptor signaling pathway
B0007612biological_processlearning
B0007613biological_processmemory
B0008284biological_processpositive regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0008544biological_processepidermis development
B0008584biological_processmale gonad development
B0009887biological_processanimal organ morphogenesis
B0009897cellular_componentexternal side of plasma membrane
B0010008cellular_componentendosome membrane
B0010468biological_processregulation of gene expression
B0010557biological_processpositive regulation of macromolecule biosynthetic process
B0010906biological_processregulation of glucose metabolic process
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0019904molecular_functionprotein domain specific binding
B0030238biological_processmale sex determination
B0030295molecular_functionprotein kinase activator activity
B0030325biological_processadrenal gland development
B0030335biological_processpositive regulation of cell migration
B0030424cellular_componentaxon
B0031017biological_processexocrine pancreas development
B0031623biological_processreceptor internalization
B0031981cellular_componentnuclear lumen
B0031994molecular_functioninsulin-like growth factor I binding
B0031995molecular_functioninsulin-like growth factor II binding
B0032590cellular_componentdendrite membrane
B0032809cellular_componentneuronal cell body membrane
B0032869biological_processcellular response to insulin stimulus
B0038024molecular_functioncargo receptor activity
B0042593biological_processglucose homeostasis
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043235cellular_componentreceptor complex
B0043243biological_processpositive regulation of protein-containing complex disassembly
B0043410biological_processpositive regulation of MAPK cascade
B0043548molecular_functionphosphatidylinositol 3-kinase binding
B0043559molecular_functioninsulin binding
B0043560molecular_functioninsulin receptor substrate binding
B0044877molecular_functionprotein-containing complex binding
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0045725biological_processpositive regulation of glycogen biosynthetic process
B0045821biological_processpositive regulation of glycolytic process
B0045840biological_processpositive regulation of mitotic nuclear division
B0045893biological_processpositive regulation of DNA-templated transcription
B0045995biological_processregulation of embryonic development
B0046326biological_processpositive regulation of D-glucose import
B0046718biological_processsymbiont entry into host cell
B0046777biological_processprotein autophosphorylation
B0048513biological_processanimal organ development
B0048639biological_processpositive regulation of developmental growth
B0048731biological_processsystem development
B0051130biological_processpositive regulation of cellular component organization
B0051239biological_processregulation of multicellular organismal process
B0051425molecular_functionPTB domain binding
B0051446biological_processpositive regulation of meiotic cell cycle
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0060267biological_processpositive regulation of respiratory burst
B0070062cellular_componentextracellular exosome
B0071363biological_processcellular response to growth factor stimulus
B0097062biological_processdendritic spine maintenance
B0097242biological_processamyloid-beta clearance
B0150104biological_processtransport across blood-brain barrier
B1990535biological_processneuron projection maintenance
B2000194biological_processregulation of female gonad development
C0005179molecular_functionhormone activity
C0005576cellular_componentextracellular region
C0006006biological_processglucose metabolic process
C0007165biological_processsignal transduction
C1901701biological_processcellular response to oxygen-containing compound
D0005179molecular_functionhormone activity
D0005576cellular_componentextracellular region
D0006006biological_processglucose metabolic process
D0007165biological_processsignal transduction
D1901701biological_processcellular response to oxygen-containing compound
E0005179molecular_functionhormone activity
E0005576cellular_componentextracellular region
E0006006biological_processglucose metabolic process
E0007165biological_processsignal transduction
E1901701biological_processcellular response to oxygen-containing compound
F0005179molecular_functionhormone activity
F0005576cellular_componentextracellular region
F0006006biological_processglucose metabolic process
F0007165biological_processsignal transduction
F1901701biological_processcellular response to oxygen-containing compound
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues29
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGnardiikgeaetr.....VAVK
ChainResidueDetails
ALEU990-LYS1018
site_idPS00239
Number of Residues9
DetailsRECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYetdYYR
ChainResidueDetails
AASP1144-ARG1152
site_idPS00262
Number of Residues15
DetailsINSULIN Insulin family signature. CCTSiCSlyqLenyC
ChainResidueDetails
CCYS61-CYS75
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsRegion: {"description":"Insulin-binding"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsSite: {"description":"Insulin-binding","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16894147","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23302862","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2983222","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16894147","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23302862","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16894147","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23302862","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16894147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16894147","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"1472036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues
DetailsM-CSA 246
ChainResidueDetails
site_idMCSA2
Number of Residues
DetailsM-CSA 246
ChainResidueDetails

238582

PDB entries from 2025-07-09

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