6PQP
Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC
Summary for 6PQP
Entry DOI | 10.2210/pdb6pqp/pdb |
EMDB information | 20449 20450 20451 |
Descriptor | Transient receptor potential cation channel subfamily A member 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzylthioformamide, ... (5 entities in total) |
Functional Keywords | ion channel, trp channel, trpa channel, trpa1 channel, irritant sensing, bitc, membrane protein, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 545684.93 |
Authors | Suo, Y.,Wang, Z.,Zubcevic, L.,Hsu, A.L.,He, Q.,Borgnia, M.J.,Ji, R.-R.,Lee, S.-Y. (deposition date: 2019-07-09, release date: 2020-01-08, Last modification date: 2020-07-29) |
Primary citation | Suo, Y.,Wang, Z.,Zubcevic, L.,Hsu, A.L.,He, Q.,Borgnia, M.J.,Ji, R.R.,Lee, S.Y. Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105:882-, 2020 Cited by PubMed: 31866091DOI: 10.1016/j.neuron.2019.11.023 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.06 Å) |
Structure validation
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