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6PEB

Crystal Structure of human NAMPT in complex with NVP-LTM976

Summary for 6PEB
Entry DOI10.2210/pdb6peb/pdb
Related6ATB
DescriptorNicotinamide phosphoribosyltransferase, N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-3-(pyridin-3-yl)azetidine-1-carboxamide, PHOSPHATE ION, ... (4 entities in total)
Functional Keywordstransferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight229621.70
Authors
Weihofen, W.A. (deposition date: 2019-06-20, release date: 2019-12-04, Last modification date: 2023-10-11)
Primary citationPalacios, D.S.,Meredith, E.L.,Kawanami, T.,Adams, C.M.,Chen, X.,Darsigny, V.,Palermo, M.,Baird, D.,George, E.L.,Guy, C.,Hewett, J.,Tierney, L.,Thigale, S.,Wang, L.,Weihofen, W.A.
Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).
Acs Med.Chem.Lett., 10:1524-1529, 2019
Cited by
PubMed: 31749905
DOI: 10.1021/acsmedchemlett.9b00325
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.46 Å)
Structure validation

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