6PEB

Crystal Structure of human NAMPT in complex with NVP-LTM976

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Nicotinamide phosphoribosyltransferase	polymer	500	56811.2	4	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (Human)	Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	E, I, M (A, B, C)	N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-3-(pyridin-3-yl)azetidine-1-carboxamide	non-polymer		412.4	3	Chemie (OE4)
3	F, G, H, J, K... (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	12	Chemie (PO4)
4	T, U, V, W (A, B, C, D)	water	water		18.0	585	Chemie (HOH)

Sequence modifications

A, B, C, D: 2 - 491 (UniProt: P43490)

PDB	External Database	Details
Leu 492	-	expression tag
Glu 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	227244.7
Non-Polymers*	Number of molecules	15
	Total formula weight	2377.0
All*	Total formula weight	229621.7

*Water molecules are not included.