Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6PEB

Crystal Structure of human NAMPT in complex with NVP-LTM976

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007165	biological_process	signal transduction
A	0007267	biological_process	cell-cell signaling
A	0007623	biological_process	circadian rhythm
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008286	biological_process	insulin receptor signaling pathway
A	0009435	biological_process	NAD biosynthetic process
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0030054	cellular_component	cell junction
A	0032922	biological_process	circadian regulation of gene expression
A	0034356	biological_process	NAD biosynthesis via nicotinamide riboside salvage pathway
A	0042802	molecular_function	identical protein binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
A	0048511	biological_process	rhythmic process
A	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
A	0060612	biological_process	adipose tissue development
A	0070062	cellular_component	extracellular exosome
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007165	biological_process	signal transduction
B	0007267	biological_process	cell-cell signaling
B	0007623	biological_process	circadian rhythm
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008286	biological_process	insulin receptor signaling pathway
B	0009435	biological_process	NAD biosynthetic process
B	0016607	cellular_component	nuclear speck
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0030054	cellular_component	cell junction
B	0032922	biological_process	circadian regulation of gene expression
B	0034356	biological_process	NAD biosynthesis via nicotinamide riboside salvage pathway
B	0042802	molecular_function	identical protein binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
B	0048511	biological_process	rhythmic process
B	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
B	0060612	biological_process	adipose tissue development
B	0070062	cellular_component	extracellular exosome
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007165	biological_process	signal transduction
C	0007267	biological_process	cell-cell signaling
C	0007623	biological_process	circadian rhythm
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008286	biological_process	insulin receptor signaling pathway
C	0009435	biological_process	NAD biosynthetic process
C	0016607	cellular_component	nuclear speck
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0030054	cellular_component	cell junction
C	0032922	biological_process	circadian regulation of gene expression
C	0034356	biological_process	NAD biosynthesis via nicotinamide riboside salvage pathway
C	0042802	molecular_function	identical protein binding
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
C	0048511	biological_process	rhythmic process
C	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
C	0060612	biological_process	adipose tissue development
C	0070062	cellular_component	extracellular exosome
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007165	biological_process	signal transduction
D	0007267	biological_process	cell-cell signaling
D	0007623	biological_process	circadian rhythm
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008286	biological_process	insulin receptor signaling pathway
D	0009435	biological_process	NAD biosynthetic process
D	0016607	cellular_component	nuclear speck
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0030054	cellular_component	cell junction
D	0032922	biological_process	circadian regulation of gene expression
D	0034356	biological_process	NAD biosynthesis via nicotinamide riboside salvage pathway
D	0042802	molecular_function	identical protein binding
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
D	0048511	biological_process	rhythmic process
D	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
D	0060612	biological_process	adipose tissue development
D	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue OE4 A 601

Chain	Residue
A	TYR188
A	ILE351
A	HOH737
A	HOH751
B	ASP16
B	TYR18
A	HIS191
A	PHE193
A	ARG196
A	ASP219
A	VAL242
A	SER275
A	PRO307
A	ARG311

site_id	AC2
Number of Residues	11
Details	binding site for residue PO4 A 602

Chain	Residue
A	ARG40
A	ARG392
A	CYS397
A	SER398
A	LYS400
A	LYS415
A	HOH744
A	HOH747
A	HOH755
A	HOH826
B	HOH710

site_id	AC3
Number of Residues	8
Details	binding site for residue PO4 A 603

Chain	Residue
A	GLY383
A	GLY384
A	HOH730
A	HOH749
A	HOH769
A	HOH770
A	HOH783
A	HOH813

site_id	AC4
Number of Residues	8
Details	binding site for residue PO4 A 604

Chain	Residue
A	ARG196
A	GLU246
A	HIS247
A	ARG311
A	ASP313
B	TYR18
B	HOH729
B	HOH755

site_id	AC5
Number of Residues	12
Details	binding site for residue OE4 B 601

Chain	Residue
A	ASP16
A	TYR18
B	HIS191
B	PHE193
B	ARG196
B	ASP219
B	ALA244
B	PRO273
B	SER275
B	PRO307
B	ARG311
B	ILE351

site_id	AC6
Number of Residues	8
Details	binding site for residue PO4 B 602

Chain	Residue
A	HOH770
B	ARG40
B	ARG392
B	SER398
B	LYS400
B	HOH707
B	HOH725
B	HOH775

site_id	AC7
Number of Residues	8
Details	binding site for residue PO4 B 603

Chain	Residue
A	HOH826
B	GLY355
B	GLY383
B	GLY384
B	HOH703
B	HOH706
B	HOH717
B	HOH773

site_id	AC8
Number of Residues	7
Details	binding site for residue PO4 B 604

Chain	Residue
A	TYR18
A	HOH793
B	GLU246
B	HIS247
B	ARG311
B	ASP313
B	HOH738

site_id	AC9
Number of Residues	16
Details	binding site for residue OE4 C 601

Chain	Residue
C	TYR188
C	HIS191
C	PHE193
C	ARG196
C	ASP219
C	VAL242
C	ALA244
C	PRO273
C	SER275
C	ILE309
C	ARG311
C	ILE351
C	PO4604
C	HOH757
C	HOH768
D	TYR18

site_id	AD1
Number of Residues	5
Details	binding site for residue PO4 C 602

Chain	Residue
C	ARG40
C	ARG392
C	SER398
C	LYS400
C	HOH709

site_id	AD2
Number of Residues	7
Details	binding site for residue PO4 C 603

Chain	Residue
C	GLY383
C	GLY384
C	HOH716
C	HOH740
C	HOH754
C	GLY353
C	GLY355

site_id	AD3
Number of Residues	9
Details	binding site for residue PO4 C 604

Chain	Residue
C	ARG196
C	GLU246
C	HIS247
C	ARG311
C	ASP313
C	OE4601
C	HOH703
D	TYR18
D	HOH726

site_id	AD4
Number of Residues	6
Details	binding site for residue PO4 D 601

Chain	Residue
D	ARG40
D	ARG392
D	SER398
D	LYS400
D	HOH702
D	HOH717

site_id	AD5
Number of Residues	6
Details	binding site for residue PO4 D 602

Chain	Residue
D	GLY353
D	GLY355
D	GLY381
D	GLY383
D	GLY384
D	GLY385

site_id	AD6
Number of Residues	7
Details	binding site for residue PO4 D 603

Chain	Residue
C	TYR18
C	LYS400
C	HOH705
D	ARG196
D	GLU246
D	HIS247
D	ARG311

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	BINDING:

Chain	Residue	Details
A	ARG196
B	HIS247
B	ARG311
B	GLY353
B	GLY384
B	ARG392
C	ARG196
C	ASP219
C	HIS247
C	ARG311
C	GLY353
A	ASP219
C	GLY384
C	ARG392
D	ARG196
D	ASP219
D	HIS247
D	ARG311
D	GLY353
D	GLY384
D	ARG392
A	HIS247
A	ARG311
A	GLY353
A	GLY384
A	ARG392
B	ARG196
B	ASP219

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:15592455

Chain	Residue	Details
A	TYR188
B	TYR188
C	TYR188
D	TYR188

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER472
B	SER472
C	SER472
D	SER472

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)