6ORV
Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor
This is a non-PDB format compatible entry.
Summary for 6ORV
Entry DOI | 10.2210/pdb6orv/pdb |
EMDB information | 20179 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | g-coupled protein receptor, gpcr, non-peptide angonist, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 164824.63 |
Authors | Belousoff, M.J.,Liang, Y.L.,Danev, R. (deposition date: 2019-05-01, release date: 2020-01-08, Last modification date: 2024-10-16) |
Primary citation | Zhao, P.,Liang, Y.L.,Belousoff, M.J.,Deganutti, G.,Fletcher, M.M.,Willard, F.S.,Bell, M.G.,Christe, M.E.,Sloop, K.W.,Inoue, A.,Truong, T.T.,Clydesdale, L.,Furness, S.G.B.,Christopoulos, A.,Wang, M.W.,Miller, L.J.,Reynolds, C.A.,Danev, R.,Sexton, P.M.,Wootten, D. Activation of the GLP-1 receptor by a non-peptidic agonist. Nature, 577:432-436, 2020 Cited by PubMed: 31915381DOI: 10.1038/s41586-019-1902-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
Download full validation report