6MVD
Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in complex with isopropyl dodec-11-enylfluorophosphonate (IDFP) and a small molecule activator
Replaces: 6DTJSummary for 6MVD
Entry DOI | 10.2210/pdb6mvd/pdb |
Descriptor | Phosphatidylcholine-sterol acyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose, propan-2-yl hydrogen (R)-ethylphosphonate, ... (7 entities in total) |
Functional Keywords | lcat, acyltransferase, cholesterol, activator, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 90375.54 |
Authors | Manthei, K.A.,Chang, L.,Tesmer, J.J.G. (deposition date: 2018-10-25, release date: 2018-12-05, Last modification date: 2023-10-11) |
Primary citation | Manthei, K.A.,Yang, S.M.,Baljinnyam, B.,Chang, L.,Glukhova, A.,Yuan, W.,Freeman, L.A.,Maloney, D.J.,Schwendeman, A.,Remaley, A.T.,Jadhav, A.,Tesmer, J.J. Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol. Elife, 7:-, 2018 Cited by PubMed: 30479275DOI: 10.7554/eLife.41604 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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