6LTV
Crystal Structure of I122A/I330A variant of S-adenosylmethionine synthetase from Cryptosporidium hominis in complex with ONB-SAM (2-nitro benzyme S-adenosyl-methionine)
Summary for 6LTV
Entry DOI | 10.2210/pdb6ltv/pdb |
Descriptor | S-adenosylmethionine synthase, TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | triphosphate, s-adenosylmethionine synthetase, transferase |
Biological source | Cryptosporidium hominis |
Total number of polymer chains | 2 |
Total formula weight | 93347.93 |
Authors | Singh, R.K.,Michailidou, F.,Rentmeister, A.,Kuemmel, D. (deposition date: 2020-01-23, release date: 2020-10-21, Last modification date: 2023-11-29) |
Primary citation | Michailidou, F.,Klocker, N.,Cornelissen, N.V.,Singh, R.K.,Peters, A.,Ovcharenko, A.,Kummel, D.,Rentmeister, A. Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions. Angew.Chem.Int.Ed.Engl., 60:480-485, 2021 Cited by PubMed: 33017502DOI: 10.1002/anie.202012623 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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