6LTV
Crystal Structure of I122A/I330A variant of S-adenosylmethionine synthetase from Cryptosporidium hominis in complex with ONB-SAM (2-nitro benzyme S-adenosyl-methionine)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | S-adenosylmethionine synthase | polymer | 414 | 45871.2 | 2 | UniProt (A0A0S4TKQ5) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773) In PDB | Cryptosporidium hominis | |
2 | A, B | TRIPHOSPHATE | non-polymer | 258.0 | 2 | Chemie (3PO) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A, B | [(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[(3R)-3-azanyl-4-oxidanyl-4-oxidanylidene-butyl]-[(2-nitrophenyl)methyl]sulfanium | non-polymer | 520.5 | 2 | Chemie (EU9) | |||
5 | water | water | 18.0 | 367 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 406 (UniProt: A0A0S4TKQ5)
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
Ala -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Ala 122 | Ile 122 | variant |
Ala 330 | Ile 330 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 91742.3 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1605.6 | |
All* | Total formula weight | 93347.9 |