6L88

Crystal structure of mineralocorticoid receptor ligand binding domain in complex with esaxerenone

Summary for 6L88

Entry DOI	10.2210/pdb6l88/pdb
Descriptor	Mineralocorticoid receptor, 1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide (2 entities in total)
Functional Keywords	nuclear receptor, hypertension, nuclear protein, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	118504.61
Authors	Takahashi, M.,Hanzawa, H. (deposition date: 2019-11-05, release date: 2020-02-12, Last modification date: 2023-11-22)
Primary citation	Takahashi, M.,Ubukata, O.,Homma, T.,Asoh, Y.,Honzumi, M.,Hayashi, N.,Saito, K.,Tsuruoka, H.,Aoki, K.,Hanzawa, H. Crystal structure of the mineralocorticoid receptor ligand-binding domain in complex with a potent and selective nonsteroidal blocker, esaxerenone (CS-3150). Febs Lett., 594:1615-1623, 2020 Cited by PubMed: 31991486 DOI: 10.1002/1873-3468.13746 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation