6L88
Crystal structure of mineralocorticoid receptor ligand binding domain in complex with esaxerenone
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue E6R A 1001 |
| Chain | Residue |
| A | LEU769 |
| A | MET852 |
| A | TYR869 |
| A | LYS873 |
| A | ALA773 |
| A | GLN776 |
| A | TRP806 |
| A | SER810 |
| A | ALA813 |
| A | LEU814 |
| A | ARG817 |
| A | PHE829 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue E6R B 1001 |
| Chain | Residue |
| B | LEU769 |
| B | ALA773 |
| B | GLN776 |
| B | TRP806 |
| B | SER810 |
| B | ALA813 |
| B | ARG817 |
| B | TYR869 |
| B | LYS873 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue E6R C 1001 |
| Chain | Residue |
| C | LEU769 |
| C | ALA773 |
| C | GLN776 |
| C | TRP806 |
| C | SER810 |
| C | ALA813 |
| C | LEU814 |
| C | ARG817 |
| C | MET852 |
| C | TYR869 |
| C | LYS873 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue E6R D 1001 |
| Chain | Residue |
| D | LEU769 |
| D | ALA773 |
| D | GLN776 |
| D | TRP806 |
| D | SER810 |
| D | ALA813 |
| D | ARG817 |
| D | MET845 |
| D | MET852 |
| D | TYR869 |
| D | LYS873 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Region: {"description":"Important for coactivator binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15908963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15967794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15967794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
