6L88
Crystal structure of mineralocorticoid receptor ligand binding domain in complex with esaxerenone
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue E6R A 1001 |
| Chain | Residue |
| A | LEU769 |
| A | MET852 |
| A | TYR869 |
| A | LYS873 |
| A | ALA773 |
| A | GLN776 |
| A | TRP806 |
| A | SER810 |
| A | ALA813 |
| A | LEU814 |
| A | ARG817 |
| A | PHE829 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue E6R B 1001 |
| Chain | Residue |
| B | LEU769 |
| B | ALA773 |
| B | GLN776 |
| B | TRP806 |
| B | SER810 |
| B | ALA813 |
| B | ARG817 |
| B | TYR869 |
| B | LYS873 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue E6R C 1001 |
| Chain | Residue |
| C | LEU769 |
| C | ALA773 |
| C | GLN776 |
| C | TRP806 |
| C | SER810 |
| C | ALA813 |
| C | LEU814 |
| C | ARG817 |
| C | MET852 |
| C | TYR869 |
| C | LYS873 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue E6R D 1001 |
| Chain | Residue |
| D | LEU769 |
| D | ALA773 |
| D | GLN776 |
| D | TRP806 |
| D | SER810 |
| D | ALA813 |
| D | ARG817 |
| D | MET845 |
| D | MET852 |
| D | TYR869 |
| D | LYS873 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15908963, ECO:0000269|PubMed:15967794, ECO:0007744|PDB:1YA3, ECO:0007744|PDB:2AA5, ECO:0007744|PDB:2AA6 |
| Chain | Residue | Details |
| A | ASN770 | |
| D | ASN770 | |
| D | GLN776 | |
| D | ARG817 | |
| A | GLN776 | |
| A | ARG817 | |
| B | ASN770 | |
| B | GLN776 | |
| B | ARG817 | |
| C | ASN770 | |
| C | GLN776 | |
| C | ARG817 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15967794, ECO:0007744|PDB:2AA5, ECO:0007744|PDB:2AA6 |
| Chain | Residue | Details |
| A | THR945 | |
| B | THR945 | |
| C | THR945 | |
| D | THR945 |
