6L88
Crystal structure of mineralocorticoid receptor ligand binding domain in complex with esaxerenone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Mineralocorticoid receptor | polymer | 251 | 29159.7 | 4 | UniProt (P08235) Pfam (PF00104) | Homo sapiens (Human) | MR,Nuclear receptor subfamily 3 group C member 2 |
| 2 | E, F, G, H (A, B, C, D) | 1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide | non-polymer | 466.5 | 4 | Chemie (E6R) |
Sequence modifications
A, B, C, D: 735 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Gly 734 | - | expression tag |
| Ser 808 | Cys 808 | engineered mutation |
| Ser 910 | Cys 910 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 116638.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1865.9 | |
| All* | Total formula weight | 118504.6 |
