6KXY
Human PPAR alpha ligand binding domain in complex with a synthetic agonist (compound B)
Summary for 6KXY
Entry DOI | 10.2210/pdb6kxy/pdb |
Descriptor | Peroxisome proliferator-activated receptor alpha, PGC1alpha, 6-ethyl-1-(4-fluorophenyl)-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid, ... (4 entities in total) |
Functional Keywords | agonist, complex, nuclear receptor, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 33446.00 |
Authors | Yoshida, T.,Tachibana, K.,Oki, H.,Doi, M.,Fukuda, S.,Yuzuriha, T.,Tabata, R.,Ishimoto, K.,Kawahara, K.,Ohkubo, T.,Miyachi, H.,Doi, T. (deposition date: 2019-09-14, release date: 2020-05-20, Last modification date: 2023-11-22) |
Primary citation | Yoshida, T.,Oki, H.,Doi, M.,Fukuda, S.,Yuzuriha, T.,Tabata, R.,Ishimoto, K.,Kawahara, K.,Ohkubo, T.,Miyachi, H.,Doi, T.,Tachibana, K. Structural Basis for PPAR alpha Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives. Sci Rep, 10:7623-7623, 2020 Cited by PubMed: 32376995DOI: 10.1038/s41598-020-64527-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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