6KNZ
Crystal structure of T2R-TTL-KXO1 complex
Summary for 6KNZ
Entry DOI | 10.2210/pdb6knz/pdb |
Descriptor | Tubulin alpha-1B chain, 2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]-~{N}-(phenylmethyl)ethanamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | tubulin, inhibitor, complex, structural protein |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 6 |
Total formula weight | 265438.45 |
Authors | |
Primary citation | Niu, L.,Yang, J.,Yan, W.,Yu, Y.,Zheng, Y.,Ye, H.,Chen, Q.,Chen, L. Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of beta-tubulin explains KXO1's low clinical toxicity. J.Biol.Chem., 294:18099-18108, 2019 Cited by PubMed: 31628188DOI: 10.1074/jbc.RA119.010732 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.475 Å) |
Structure validation
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