6KNR
Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699
Summary for 6KNR
Entry DOI | 10.2210/pdb6knr/pdb |
Descriptor | Estrogen-related receptor gamma, (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol (3 entities in total) |
Functional Keywords | estrogen-related receptor gamma, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 55747.14 |
Authors | |
Primary citation | Kim, J.,Hwang, H.,Yoon, H.,Lee, J.E.,Oh, J.M.,An, H.,Ji, H.D.,Lee, S.,Cha, E.,Ma, M.J.,Kim, D.S.,Lee, S.J.,Kadayat, T.M.,Song, J.,Lee, S.W.,Jeon, J.H.,Park, K.G.,Lee, I.K.,Jeon, Y.H.,Chin, J.,Cho, S.J. An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer. Eur.J.Med.Chem., 205:112501-112501, 2020 Cited by PubMed: 32758860DOI: 10.1016/j.ejmech.2020.112501 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.804 Å) |
Structure validation
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