6JKE
Discovery and the crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2.
Summary for 6JKE
| Entry DOI | 10.2210/pdb6jke/pdb |
| Descriptor | Bromodomain-containing protein 2, 7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione, SULFATE ION, ... (8 entities in total) |
| Functional Keywords | bet family, bet inhibitor, bromodomain inhibitor, brd2-bd1 inhibitor, transcription |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 3 |
| Total formula weight | 44485.61 |
| Authors | Padmanabhan, B.,Mathur, S.,Deshmukh, P. (deposition date: 2019-02-28, release date: 2020-07-01, Last modification date: 2023-11-22) |
| Primary citation | Deshmukh, P.,Mathur, S.,Gangadharan, G.,Krishnappa, G.,Dalavaikodihalli Nanjaiah, N.,Padmanabhan, B. Novel pyrano 1,3 oxazine based ligand inhibits the epigenetic reader hBRD2 in glioblastoma. Biochem.J., 477:2263-2279, 2020 Cited by PubMed: 32484211DOI: 10.1042/BCJ20200339 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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