6JKE

Discovery and the crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2.

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue BUX A 201

Chain	Residue
A	TRP97
A	HOH386
A	HOH395
A	HOH432
A	PRO98
A	GLN101
A	VAL103
A	LYS107
A	LEU108
A	ASN156
A	ILE162
A	HOH315

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 202

Chain	Residue
A	ARG128
A	ARG129
A	HOH304
A	HOH317

---

site_id	AC3
Number of Residues	4
Details	binding site for residue DTT A 203

Chain	Residue
A	GLN94
A	ARG100
A	HOH335
A	HOH367

---

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL B 201

Chain	Residue
B	PRO98
B	VAL103
B	ASN156
B	ILE162
B	HOH317

---

site_id	AC5
Number of Residues	1
Details	binding site for residue DMS B 202

Chain	Residue
B	ARG129

---

site_id	AC6
Number of Residues	3
Details	binding site for residue PGE B 203

Chain	Residue
B	THR76
B	ASN77
B	GLN182

---

site_id	AC7
Number of Residues	5
Details	binding site for residue DMS C 201

Chain	Residue
C	VAL103
C	LEU110
C	ASN156
C	ILE162
C	HOH310

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 C 202

Chain	Residue
B	ARG100
C	ARG128
C	ASN132
C	TYR134
C	HOH350

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA96-TYR155

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:37731000, ECO:0007744|PDB:8SB6

Chain	Residue	Details
A	ASP112
C	TYR155
C	ASN156
C	LYS157
A	TYR155
A	ASN156
A	LYS157
B	ASP112
B	TYR155
B	ASN156
B	LYS157
C	ASP112

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20048151, ECO:0007744|PDB:2DVQ, ECO:0007744|PDB:2DVS

Chain	Residue	Details
A	ASP160
A	ASP161
B	ASP160
B	ASP161
C	ASP160
C	ASP161

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