6JKE
Discovery and the crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue BUX A 201 |
| Chain | Residue |
| A | TRP97 |
| A | HOH386 |
| A | HOH395 |
| A | HOH432 |
| A | PRO98 |
| A | GLN101 |
| A | VAL103 |
| A | LYS107 |
| A | LEU108 |
| A | ASN156 |
| A | ILE162 |
| A | HOH315 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | ARG128 |
| A | ARG129 |
| A | HOH304 |
| A | HOH317 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue DTT A 203 |
| Chain | Residue |
| A | GLN94 |
| A | ARG100 |
| A | HOH335 |
| A | HOH367 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 201 |
| Chain | Residue |
| B | PRO98 |
| B | VAL103 |
| B | ASN156 |
| B | ILE162 |
| B | HOH317 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue DMS B 202 |
| Chain | Residue |
| B | ARG129 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue PGE B 203 |
| Chain | Residue |
| B | THR76 |
| B | ASN77 |
| B | GLN182 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue DMS C 201 |
| Chain | Residue |
| C | VAL103 |
| C | LEU110 |
| C | ASN156 |
| C | ILE162 |
| C | HOH310 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 202 |
| Chain | Residue |
| B | ARG100 |
| C | ARG128 |
| C | ASN132 |
| C | TYR134 |
| C | HOH350 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
