6ITO
Crystal structure of pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, AMP and inhibitor Ribose 5-Phosphate
Summary for 6ITO
Entry DOI | 10.2210/pdb6ito/pdb |
Related | 5WSC |
Descriptor | Pyruvate kinase, MAGNESIUM ION, OXALATE ION, ... (6 entities in total) |
Functional Keywords | pyruvate kinase, glycolysis, tetramer, allostery, synergism, phospho transferase, transferase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 4 |
Total formula weight | 206815.96 |
Authors | Zhong, W.,Cai, Q.,El Sahili, A.,Mu, Y.,Lescar, J.,Dedon, P.C. (deposition date: 2018-11-24, release date: 2019-08-14, Last modification date: 2023-11-22) |
Primary citation | Zhong, W.,Guo, J.,Cui, L.,Chionh, Y.H.,Li, K.,El Sahili, A.,Cai, Q.,Yuan, M.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.,Mu, Y.,Lescar, J.,Dedon, P.C. Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis. J.Mol.Biol., 431:3690-3705, 2019 Cited by PubMed: 31381898DOI: 10.1016/j.jmb.2019.07.033 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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