6ITO
Crystal structure of pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, AMP and inhibitor Ribose 5-Phosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase | polymer | 475 | 51014.3 | 4 | UniProt (P9WKE5) Pfam (PF00224) Pfam (PF02887) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | PK |
| 2 | E, I, M, Q (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 3 | F, J, N, R (A, B, C, D) | OXALATE ION | non-polymer | 88.0 | 4 | Chemie (OXL) PubChem (71081) | |||
| 4 | G, K, O, S (A, B, C, D) | RIBOSE-5-PHOSPHATE | non-polymer | 230.1 | 4 | Chemie (R5P) PubChem (230) PubChem (44588263) PubChem (77982) PubChem (53393537) PubChem (188324) PubChem (441187) PubChem (88507863) PubChem (88508108) PubChem (85049) PubChem (6101623) PubChem (14029334) PubChem (135075808) | |||
| 5 | H, L, P, T (A, B, C, D) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 4 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 6 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 540 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 472 (UniProt: P9WKE5)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 204057.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2758.6 | |
| All* | Total formula weight | 206816.0 |
