6HAR

Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C

Summary for 6HAR

Entry DOI	10.2210/pdb6har/pdb
Descriptor	PRSS3 protein, Amyloid-beta A4 protein, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	prss3, mesotrypsin, serine protease, kunitz type inhibitor, appi, protein fibril
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	33430.50
Authors	Shahar, A.,Cohen, I.,Radisky, E.,Papo, N. (deposition date: 2018-08-08, release date: 2019-02-06, Last modification date: 2024-01-17)
Primary citation	Cohen, I.,Coban, M.,Shahar, A.,Sankaran, B.,Hockla, A.,Lacham, S.,Caulfield, T.R.,Radisky, E.S.,Papo, N. Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J.Biol.Chem., 294:5105-5120, 2019 Cited by PubMed: 30700553 DOI: 10.1074/jbc.RA118.007292 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.497 Å)

Structure validation