6GFE
High-resolution Structure of a therapeutic full-length anti-NPRA Antibody with exceptional Conformational Diversity
Summary for 6GFE
Entry DOI | 10.2210/pdb6gfe/pdb |
Descriptor | Immunoglobulin gamma-4 heavy chain, Immunoglobulin gamma-4 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | immunoglobulin, antibody, natriuretic peptide receptor a, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 149267.04 |
Authors | Hoerer, S. (deposition date: 2018-04-30, release date: 2019-05-15, Last modification date: 2020-07-29) |
Primary citation | Blech, M.,Horer, S.,Kuhn, A.B.,Kube, S.,Goddeke, H.,Kiefer, H.,Zang, Y.,Alber, Y.,Kast, S.M.,Westermann, M.,Tully, M.D.,Schafer, L.V.,Garidel, P. Structure of a Therapeutic Full-Length Anti-NPRA IgG4 Antibody: Dissecting Conformational Diversity. Biophys.J., 116:1637-1649, 2019 Cited by PubMed: 31023536DOI: 10.1016/j.bpj.2019.03.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report