6FYK

X-Ray structure of CLK2-KD(136-496)/Indazole1 at 2.39A

Summary for 6FYK

Entry DOI	10.2210/pdb6fyk/pdb
Related	6FYI
Descriptor	Dual specificity protein kinase CLK2, (2~{S})-4-methyl-1-[5-(3-methyl-2~{H}-indazol-5-yl)pyridin-3-yl]oxy-pentan-2-amine (3 entities in total)
Functional Keywords	splicing, phosphotransferase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	129275.76
Authors	Kallen, J. (deposition date: 2018-03-12, release date: 2018-07-18, Last modification date: 2024-01-17)
Primary citation	Kallen, J.,Bergsdorf, C.,Arnaud, B.,Bernhard, M.,Brichet, M.,Cobos-Correa, A.,Elhajouji, A.,Freuler, F.,Galimberti, I.,Guibourdenche, C.,Haenni, S.,Holzinger, S.,Hunziker, J.,Izaac, A.,Kaufmann, M.,Leder, L.,Martus, H.J.,von Matt, P.,Polyakov, V.,Roethlisberger, P.,Roma, G.,Stiefl, N.,Uteng, M.,Lerchner, A. X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome. ChemMedChem, 13:1997-2007, 2018 Cited by PubMed: 29985556 DOI: 10.1002/cmdc.201800344 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.39 Å)

Structure validation