6FYI

X-ray Structure of CLK2-KD(130-496)/TG003 at 2.6A

Summary for 6FYI

Entry DOI	10.2210/pdb6fyi/pdb
Descriptor	Dual specificity protein kinase CLK2, (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one (3 entities in total)
Functional Keywords	splicing, phosphotransferase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43637.51
Authors	Kallen, J. (deposition date: 2018-03-12, release date: 2018-07-18, Last modification date: 2024-01-17)
Primary citation	Kallen, J.,Bergsdorf, C.,Arnaud, B.,Bernhard, M.,Brichet, M.,Cobos-Correa, A.,Elhajouji, A.,Freuler, F.,Galimberti, I.,Guibourdenche, C.,Haenni, S.,Holzinger, S.,Hunziker, J.,Izaac, A.,Kaufmann, M.,Leder, L.,Martus, H.J.,von Matt, P.,Polyakov, V.,Roethlisberger, P.,Roma, G.,Stiefl, N.,Uteng, M.,Lerchner, A. X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome. ChemMedChem, 13:1997-2007, 2018 Cited by PubMed: 29985556 DOI: 10.1002/cmdc.201800344 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation