6FYI
X-ray Structure of CLK2-KD(130-496)/TG003 at 2.6A
Summary for 6FYI
Entry DOI | 10.2210/pdb6fyi/pdb |
Descriptor | Dual specificity protein kinase CLK2, (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one (3 entities in total) |
Functional Keywords | splicing, phosphotransferase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43637.51 |
Authors | Kallen, J. (deposition date: 2018-03-12, release date: 2018-07-18, Last modification date: 2024-01-17) |
Primary citation | Kallen, J.,Bergsdorf, C.,Arnaud, B.,Bernhard, M.,Brichet, M.,Cobos-Correa, A.,Elhajouji, A.,Freuler, F.,Galimberti, I.,Guibourdenche, C.,Haenni, S.,Holzinger, S.,Hunziker, J.,Izaac, A.,Kaufmann, M.,Leder, L.,Martus, H.J.,von Matt, P.,Polyakov, V.,Roethlisberger, P.,Roma, G.,Stiefl, N.,Uteng, M.,Lerchner, A. X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome. ChemMedChem, 13:1997-2007, 2018 Cited by PubMed: 29985556DOI: 10.1002/cmdc.201800344 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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