6FAZ
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the positive allosteric modulator TDPAM01 at 1.4 A resolution.
Summary for 6FAZ
Entry DOI | 10.2210/pdb6faz/pdb |
Descriptor | Glutamate receptor 2, SULFATE ION, DI(HYDROXYETHYL)ETHER, ... (10 entities in total) |
Functional Keywords | ampa receptor, glua2, ligand-binding domain, glua2-s1s2j, positive allosteric modulator, membrane protein |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 2 |
Total formula weight | 60905.80 |
Authors | Nielsen, L.,Laulumaa, S.,Kastrup, J.S. (deposition date: 2017-12-18, release date: 2018-11-21, Last modification date: 2024-01-17) |
Primary citation | Drapier, T.,Geubelle, P.,Bouckaert, C.,Nielsen, L.,Laulumaa, S.,Goffin, E.,Dilly, S.,Francotte, P.,Hanson, J.,Pochet, L.,Kastrup, J.S.,Pirotte, B. Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds. J. Med. Chem., 61:5279-5291, 2018 Cited by PubMed: 29775064DOI: 10.1021/acs.jmedchem.8b00250 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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