6FAZ

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the positive allosteric modulator TDPAM01 at 1.4 A resolution.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glutamate receptor 2	polymer	264	29278.7	2	UniProt (P19491) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	C, D, E, Q, R (A, B)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
3	F, G (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
4	H, I, J, K, S (A, B)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5	L, T, U, V, W (A, B)	CHLORIDE ION	non-polymer		35.5	5	Chemie (CL)
6	M, X, Y (A, B)	ACETATE ION	non-polymer		59.0	3	Chemie (ACT)
7	N, Z (A, B)	GLUTAMIC ACID	non-polymer		147.1	2	Chemie (GLU)
8	AA, O (B, A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
9	P (B)	6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide)	non-polymer		422.5	1	Chemie (D45)
10	BA, CA (A, B)	water	water		18.0	661	Chemie (HOH)

Sequence modifications

A, B: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag

A, B: 120 - 264 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58557.5
Non-Polymers*	Number of molecules	25
	Total formula weight	2348.3
All*	Total formula weight	60905.8

*Water molecules are not included.