6FAZ
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the positive allosteric modulator TDPAM01 at 1.4 A resolution.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Glutamate receptor 2 | polymer | 264 | 29278.7 | 2 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | A, B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 4 | A, B | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | A, B | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 6 | A, B | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 7 | A, B | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) | |||
| 8 | B, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 9 | B | 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) | non-polymer | 422.5 | 1 | Chemie (D45) | |||
| 10 | water | water | 18.0 | 661 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 117 (UniProt: P19491)
A, B: 120 - 264 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 2 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 118 | - | linker |
| Thr 119 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58557.5 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 2348.3 | |
| All* | Total formula weight | 60905.8 |
