6FAZ

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the positive allosteric modulator TDPAM01 at 1.4 A resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 301

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH434
A	HOH467
A	HOH489
A	HOH603

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	HOH420
A	HOH506
A	LYS82
A	LYS116

---

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 303

Chain	Residue
A	GLU97
A	ASP101
A	PHE102
A	HOH433
A	HOH574
A	HOH649
B	LYS104

---

site_id	AC4
Number of Residues	3
Details	binding site for residue PEG A 304

Chain	Residue
A	GLY28
A	ARG31
A	LYS52

---

site_id	AC5
Number of Residues	5
Details	binding site for residue PEG A 305

Chain	Residue
A	GLU33
A	LYS253
A	TRP254
A	LYS258
A	HOH549

---

site_id	AC6
Number of Residues	3
Details	binding site for residue GOL A 306

Chain	Residue
A	ARG148
A	TRP159
A	ARG163

---

site_id	AC7
Number of Residues	3
Details	binding site for residue GOL A 307

Chain	Residue
A	HIS46
A	LYS240
A	GLN244

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL A 308

Chain	Residue
A	SER194
A	GLU198
A	LYS210
A	ASN214
A	HOH595

---

site_id	AC9
Number of Residues	11
Details	binding site for residue GOL A 309

Chain	Residue
A	LEU78
A	VAL79
A	GLY81
A	LYS117
A	MET209
A	PRO225
A	LYS226
A	HOH401
A	HOH403
A	HOH481
A	HOH632

---

site_id	AD1
Number of Residues	2
Details	binding site for residue CL A 310

Chain	Residue
A	LYS4
A	THR5

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ACT A 311

Chain	Residue
A	ILE152
A	ALA153
A	HOH439
A	HOH619

---

site_id	AD3
Number of Residues	13
Details	binding site for residue GLU A 312

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193
A	TYR220
A	HOH432
A	HOH468
A	HOH488

---

site_id	AD4
Number of Residues	4
Details	binding site for residue EDO A 313

Chain	Residue
A	ASN214
A	ASP216
A	SER217
B	ASP248

---

site_id	AD5
Number of Residues	14
Details	binding site for residue D45 B 301

Chain	Residue
A	LYS104
A	PRO105
A	SER108
A	SER217
A	LYS218
A	GLY219
A	ASN242
B	LYS104
B	PRO105
B	SER108
B	LYS218
B	GLY219
B	ASN242
B	HOH524

---

site_id	AD6
Number of Residues	7
Details	binding site for residue SO4 B 302

Chain	Residue
B	SER140
B	LYS144
B	ARG148
B	HOH423
B	HOH435
B	HOH547
B	HOH570

---

site_id	AD7
Number of Residues	5
Details	binding site for residue SO4 B 303

Chain	Residue
B	ARG31
B	HOH425
B	HOH460
B	HOH482
B	HOH494

---

site_id	AD8
Number of Residues	4
Details	binding site for residue GOL B 304

Chain	Residue
B	ARG163
B	HOH598
B	ARG148
B	TRP159

---

site_id	AD9
Number of Residues	2
Details	binding site for residue CL B 305

Chain	Residue
B	ASN22
B	GLU24

---

site_id	AE1
Number of Residues	2
Details	binding site for residue CL B 306

Chain	Residue
B	HIS46
B	GLN244

---

site_id	AE2
Number of Residues	3
Details	binding site for residue CL B 307

Chain	Residue
B	LYS50
B	TYR51
B	HOH589

---

site_id	AE3
Number of Residues	1
Details	binding site for residue CL B 308

Chain	Residue
B	ALA153

---

site_id	AE4
Number of Residues	6
Details	binding site for residue ACT B 309

Chain	Residue
A	ASP248
B	ASN214
B	LEU215
B	ASP216
B	SER217
B	HOH587

---

site_id	AE5
Number of Residues	6
Details	binding site for residue ACT B 310

Chain	Residue
A	LYS104
A	HOH694
B	GLU97
B	ASP101
B	PHE102
B	HOH610

---

site_id	AE6
Number of Residues	13
Details	binding site for residue GLU B 311

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH444
B	HOH462
B	HOH463

---

site_id	AE7
Number of Residues	7
Details	binding site for residue EDO B 312

Chain	Residue
B	ALA134
B	TYR161
B	ALA165
B	GLU166
B	PRO167
B	VAL169
B	ARG180

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3

---