6F6Z
Mouse Thymidylate Synthase Cocrystallized with N(4)OHdCMP and Soaked in Methylenetetrahydrofolate
Summary for 6F6Z
Entry DOI | 10.2210/pdb6f6z/pdb |
Descriptor | Thymidylate synthase, 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), (2~{S})-2-[[4-[[(6~{R})-2-azanyl-4-oxidanylidene-5,6,7,8-tetrahydro-1~{H}-pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid, ... (4 entities in total) |
Functional Keywords | enzyme, inhibitor, cofactor, transferase |
Biological source | Mus musculus (House Mouse) |
Total number of polymer chains | 2 |
Total formula weight | 71567.34 |
Authors | Wilk, P.,Jarmula, A.,Maj, P.,Rode, W. (deposition date: 2017-12-06, release date: 2019-01-30, Last modification date: 2024-01-17) |
Primary citation | Maj, P.,Jarmula, A.,Wilk, P.,Prokopowicz, M.,Rypniewski, W.,Zielinski, Z.,Dowiercial, A.,Bzowska, A.,Rode, W. Molecular Mechanism of Thymidylate Synthase Inhibition by N4-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies Int J Mol Sci, 22:-, 2021 Cited by PubMed: 33946210DOI: 10.3390/ijms22094758 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.127 Å) |
Structure validation
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